A recombinantEscherichia coliheat-stable enterotoxin b (STb) fusion protein eliciting neutralizing antibodies
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چکیده
منابع مشابه
Escherichia coli heat-stable enterotoxin b (STb) in vivo internalization within rat intestinal epithelial cells.
Heat-stable enterotoxin b (STb) is a low molecular weight toxin known to bind sulfatide, its receptor. The fate of STb bound to rat intestinal epithelium cells was followed using an anti-toxin gold labeled assay and transmission electron microscopy. The data suggest that STb toxin and the fusion protein maltose binding protein (MBP)-STb were internalized whereas its mutant I41 E-M42R with reduc...
متن کاملCharacterization of Escherichia coli strains producing heat-stable enterotoxin b (STb) isolated from humans with diarrhea.
Two of 49 cytolethal distending toxin-producing strains of Escherichia coli isolated from human stools contained the gene coding for heat-stable enterotoxin b (STb), as detected by a colony hybridization assay. The STb gene was found to be on a 70-kb plasmid also coding for heat-labile enterotoxin (pLT-I). Restriction endonuclease analysis showed the STb gene from human isolates to be similar t...
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متن کاملEffects of Escherichia coli heat-stable enterotoxin STb on intestines of mice, rats, rabbits, and piglets.
There are at least two classes of Escherichia coli heat-stable enterotoxins, STa and STb. Unlike STa, which is active in suckling mice and piglets, STb is inactive in suckling mice but active in piglets and older, weaned pigs. This study examined the activity of STb in several animals and its effect on intestinal histology and cyclic GMP levels in intestinal mucosal cells. STb did not cause flu...
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ژورنال
عنوان ژورنال: FEMS Immunology & Medical Microbiology
سال: 1996
ISSN: 0928-8244,1574-695X
DOI: 10.1111/j.1574-695x.1996.tb00257.x